Parkinson’s. Disease
Parkinson disease (PD) is a chronic, steadily progressive neurodegenerative disease. It
leads to severe motor impairment, social disadaptation, and a decrease in the quality of
patient’s life.
MSCs, similar to leukocytes, express a variety of receptors and cell adhesion molecules
involved in homing and migration to the lesion sites
In these studies, the implanted stem cells have shown a pronounced neurotrophic effect by
producing growth factors, such as GDNF, BDNF, NGF, IGF-1, and VEGF. In addition, there is
ample evidence that MSCs support the structural organization of both individual brain cells
and the neuronal network as a whole, and contribute to the survival of neurons and
oligodendrocytes in neurodestructive conditions.[18] Moreover, by exerting an
immunoregulatory effect on both local and systemic levels,[5] MSCs decrease the
inflammatory response from microglial cells, and, thus, restore the functional activity of
neurons.
The treatment of patients with PD with the use of MSCs has produced encouraging results
that suggest influence on many symptoms of the PD pathogenesis, as well as their
capability to modify the course of the disease and provide control over the manifestations
of the motor symptoms of the disease.
Surg Neurol Int. 2020; 11: 380.
