Osteoporosis
Osteoporosis, as a systematic skeletal disorder, is a common age-related bone defect which
affects women more than men. Osteoporosis cause bone mineral density (BMD) loss and
the degradation of the bone microstructure due to an abnormal imbalance between bone
formation by osteoblasts and bone resorption by osteoclasts. Additionally, MSCs population
in the BM are declined with aging; thus, their function will be limited and they cannot
contribute to bone formation any longer. Osteoporosis is of great importance mostly
because of its effect on bone fragility. It also causes back pain and decreased quality of life
which are collectively associated to high economic burden. Accordingly, suitable treatment
strategies are essential for preventing disease and improving quality of life. Current
osteoporosis treatments are principally using drug-based agents that usually stimulate
apoptosis in osteoclasts and prevent the bone resorption. However, they are associated
with some side effects and therefore do not provide patient satisfaction.
During the last decade, stem cell therapy, as a new technology, is widely developed for
bone regeneration in patients with osteoporosis. MSCs are the most extensively used stem
cell type for this disease… Allogeneic BM-MSCs therapy in glucocorticoid-induced
osteoporosis in mice models showed osteoblastogenesis and promoted bone formation.
