Degenerative disc disease (DDD), herniation and Radiculitis of lumbar, cervical and thoracic spine
Degenerative disc disease (DDD) is a common cause of lower back pain with radicular
symptoms and has a significant socioeconomic impact given the associated disability.
Limited effective conservative therapeutic options result in many turning to surgical
alternatives for management, which vary in the rate of success and also carry an increased
risk of morbidity and mortality associated with the procedures.
Patients treated with Mesenchymal Stem cells (MSCs) for pain with radicular symptoms in
the setting of DDD reported significant improvements in pain, function, and overall
subjective improvement through 6 years of follow-up.
Scheme summarizes the pathological conditions of intervertebral disc degeneration and
regenerative effects of Mesenchymal stem cells (MSCs).
AFC, annulus fibrosis cell; Bcl-2, B-cell lymphoma 2; ECM, etracellular matrix; IL,
interleukin; MMP, matrix metalloproteinase; NPC, nucleus purposes cell; TIES, tyrosine
kinase with Ig and EGF homology domains-2; TNF-alpha, tumor necrosis factor-alpha.
Cells. 2023 Sep; 12(17): 2161.
